Toxicity In Vivo Of Thermal-sprayed Silver Containing Hydroxyapatite Coating In The Rat Tibia
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Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia
To reduce the incidence of implant-associated infection, we previously developed a novel coating technology using hydroxyapatite (HA) containing silver (Ag). This study examined in vivo acute and subacute toxicity associated with the Ag-HA coating in rat tibiae. Ten-week-old rats received implantation of HA-, 2% Ag-HA-, or 50% Ag-HA-coated titanium rods. Concentrations of silver in serum, brain...
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Introduction: The degree of osseointegration determines the long-term survival and favorable outcomes of orthopedic implant use. Initial fixation is influenced by a number of factors. Hydroxyapatite (HA) coating has a good osteoconductive property and sealing effect on peri implant migration of particles that lead to osteolysis. Furthermore, HA-coated implants show desirable midterm clinical re...
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The zeta potential magnitude and the duration of its changes have been thought to be directly related to the surface reactivity, the governing of osteoconductivity and availability of valuable information in determining the anticipated in-vivo performance of implants. In this study the zeta potential of plasma sprayed hydroxyapatite (HA) was evaluated in various simulated physiological solution...
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Among bioactive ceramics, the apatite/wollastonite (A/W) glass ceramic, containing apatite and wollastonite crystals in the glassy matrix, has been largely studied because of good bioactivity and used in some fields of medicine, especially in orthopedics and dentistry. However, medical applications of bioceramic are limited to non-load bearing applications because of their poor mechanical prope...
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